Life is short, do what makes you happy.” That’s the advice that Matt got from his Dad-a world renowned physician-when Matt quit medicine to pursue stand up comedy. And those words still guide Matt today. He talks ninjas, tells jokes around the world and, in general, proves laughter is the best medicine.

Perhaps best known as the host of the FOUR TIME Emmy nominated “American Ninja Warrior” and being named the newest Celebrity Apprentice, the Boston Globe has said of Matt, “The best part about American Ninja Warrior, hands down, is when bro-host Matt Iseman roars the show’s title.” He also helms the latest spinoff, American Ninja Warrior Junior, on Universal Kids (it’s their highest rated show ever) and he headed up the spinoff, “ANW: Ninja vs Ninja” on the USA Network. Matt hosted Evel Live on History, the highest rated cable special of 2018 and makes regular visits to the Today Show. He also hosts Live Rescue on A&E following the life & death everyday heroics of First Responders.

His ongoing battle with Rheumatoid Arthritis transformed him into a strong supporter of the Arthritis Foundation, the charity he’s represented while winning Celebrity Apprentice. Yes, Arnold Schwarzenegger considers him a celebrity. For his work over the past decade and a half, Matt was named the 2018 “Arthritis Warrior of the Year.” And his battle with Renal Cell Carcinoma has made him a spokesperson for the American Cancer Society. He still serves as the Apprentice to the Boss, Arnold Schwarzenegger, hosting the Arnold Strongman Classic and helping him raise millions of dollars for the After School All Stars. Matt also supports the American Cancer Society, the Cystic Fibrosis Foundation and serves as an Ambassador for the Armed Services Arts Partnership.

Matt has been a Lip Sync Battle Champion, he’s crushed on Hollywood Game Night & Punchline and has been called “legendary” on 25 Words or Less.

Dr. Matt was a regular on Hallmark’s Home & Family, sharing his medical expertise and his unique lifestyle tips. His hosting has already earned him an Emmy Award on Clean House. He also hosted Sports Soup on Versus and Scream Play on E!. He’s starred in countless commercials, numerous sitcoms and Transformers 2.

Matt has made HERstory on RuPaul’s Secret Celebrity Drag Race, he became a Lip Sync Battle Champion, he’s crushed on Hollywood Game Night & Punchline and has been called “legendary” on 25 Words or Less.
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  • Live Rescue on A&E | Host
  • American Ninja Warrior Junior | Host
  • Evel Live 2 | Host
  • Factorious Podcast | Host
  • Ellens Game of Games – Guest Star
  • The Kelly Clarkson Show – Himself/ Gameshow Host
  • We have Saving Mom twice, change the top one to Family by Design | Host/ Producer
  • Lip Sync Battle – CHAMPION
  • Evel Live for History | Host
  • Macy’s 4th of July Fireworks Spectacular 2018 | Host
  • Extra | Co-Host
  • The Joel McHale Show with Joel McHale | Black Mirror
  • Little Big Shots | Himself
  • Red Nose Day Host for NBC
  • Pickler & Ben | Himself
  • American Dad | Announcer
  • Hollywood Game Night | Player
  • Macy’s 4th of July Fireworks Spectacular 2017 | Host
  • Today Show | CoHost 9am Hour
  • Celebrity Apprentice | Winner
  • RuPaul’s Secret Celebrity Drag Race – Bette Bordeaux/ Himself
  • Team USA Awards | Host
  • Team Ninja Warrior | Host
  • Best Time Ever | Guest Host
  • Home & Family | Host
  • Hot in Cleveland | Guest Star
  • The League | Guest Star
  • Saving Mom | Host/ Producer
  • Best of ANW | Host/ Producer
  • American Ninja Warrior | Host
  • Saving Mom | Host/Created By
  • Invisible | Host
  • Dumbest Stuff on Wheels | Narrator
  • Sports Soup | Host
  • Transformers 2 | Capt. Tim Flynn
  • Command and Conquer III: Kane’s Wrath | VO
  • Drive | Host
  • RedEye | Panelist
  • Clean House Comes Clean | Host
  • Comics Unleashed | Himself
  • Clean House | Host
  • NCIS | Guest Star
  • Courting Alex | Guest Star
  • Casino Night on GSN | Host
  • VH-1’s 100 Hottest Bodies | Guest Star
  • Premium Blend | Himself
  • Coming Attractions | Guest Host
  • Scream Play on E! | Host
  • General Hospital | Recurring
  • The Glutton Bowl | Co-host/Medical Expert
  • Talk Soup | Featured Performer
  • Drew Carey Show | Featured